For example, there may be drug interactions for those taking medications such as tricyclic antidepressants or antihistamines, warns Dr Lee. While all the aforementioned medications can be very effective, always tell your GP or pharmacist about any other medication you're taking. While this option sounds expensive, each patch lasts for 72 hours so should see you through the beginning and the end of a trip. These contain hyoscine hydrobromide, which is another name for scopolamine. Try Scopoderm Patches (opens in new tab) (£17.20 for 2). Usually used to treat muscular spasms, it works in a similar way to antihistamines in that it blocks acetylcholine receptors, which seems to help with certain motion sickness symptoms, says Dr Lee. It was also well tolerated and was no more likely to cause side effects, such as drowsiness or blurred vision," she says. "In a 2004 (opens in new tab) Cochrane review of 12 randomised controlled or parallel-arm studies, including 901 participants, scopolamine was found to be more effective in reducing travel sickness symptoms than the other treatments tested. "Scopolamine is a first-choice option for preventing travel sickness," says Dr Lee. While pricer than tablets, they can be very useful. If you don't want to take medication by mouth you can try motion sickness patches. It is an antipsychotic drug which blocks the production of dopamine – another brain neurotransmitter – and also interferes with transmission of nerve impulses to the vomiting centre," explains Dr Lee. ![]() "This can be used to treat nausea and vomiting. If you have severe symptoms, you will need motion sickness treatments from your GP. ![]() If you want to stay alert during your travels, ask your pharmacist for a non-drowsy option. And some cause drowsiness, so if you're driving they won't be suitable. 'They can also have side effects, such as drowsiness, dry mouth, constipation or blurred vision," says Dr Bond. Medication, however, is not suitable for everyone, such as people certain heart, thyroid, kidney, liver or digestive problems. Blocking the acetylcholine receptors disrupts the transmission of impulses from the vestibular nuclei in the brain to the vomiting centre," she explains. "Acetylcholine is the main neurotransmitter (chemical messenger) of the parasympathetic nervous system (PSNS). How do antihistamines prevent nausea? "Antihistamines are used for travel sickness, not because they prevent the release of histamine, but because they work by blocking acetylcholine receptors," says Dr Lee. "Of these drugs, promethazine has been shown to be the most effective antihistamine for travel sickness." ![]() ![]() "These include hyoscine hydrobromide (Kwells), promethazine (Avomine, Phenergan), cinnarizine (Stugeron), or cyclizine (Valoid)," says Dr Deborah Lee, from the Dr Fox Online Pharmacy (opens in new tab).
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